Description
Mannose-binding lectin (MBL) is also known as mannose-binding protein, mannan-binding protein (MBP), Mannose-binding protein C, Collectin-1 (COLEC1), MBL2, which belongs to the class of collectins in the C-type lectin superfamily.
MBL contains one C-type lectin domain and one collagen-like domain.
MBL has an oligomeric structure (400-700 kDa), built of subunits that contain three presumably identical peptide chains of about 30 kDa each.
MBL is calcium-dependent lectin involved in innate immune defense.
MBL binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway.
MBL binds to late apoptotic cells.
MBL may bind DNA